We believe green chemistry offers significant environmental and business benefits as it increases resource efficiency and generates less waste while enabling production cost savings that help our business perform better. Most medicines and vaccines require substantial amounts of raw materials to manufacture a single treatment dose containing active ingredients. Responsible use of chemicals is therefore a priority for our pharmaceuticals segment.
Janssen is a founding member of the American Chemical Society (ACS) Green Chemistry Institute® Pharmaceutical Roundtable, and has been participating in the European CHEM21 program since its inception in 2012. These forums offer an opportunity to share industry best practices and direct academic research to develop greener manufacturing of active pharmaceutical ingredients (APIs).
We integrate the 12 principles of green chemistry and engineering adopted by ACS into our product development practices. Typically, we generate the most significant improvements by focusing on:
- Reduction of process mass intensity (PMI)
- Reducing hazardous waste generation
- Using greener solvents
Through the use of green chemistry and engineering techniques, our HIV drug INTELENCE (etravirine) achieved an 88% reduction in the solvent use during drug product manufacturing. It’s also the first product in Janssen's portfolio to employ direct solvent reuse, which means solvents are reused in the manufacturing process instead of being disposed of as waste.